GoboLinux: Linux without /usr/lib/whatever
In a world where most Linux distros are derivatives of a few major, established distros, GoboLinux stands out with a radically different concept: making _all_ packages live in self-contained directories. Yeah, this is like /Applications in OSX, but there are no exceptions (so, no /System/Library mess!). And it's a live CD, so check it out.
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